Real-time optical window imaging of AKT-FRET biosensor mice to maximise PI3K/AKT drug targeting within the hypoxic microenvironment of pancreatic cancer. [ 2017 - 2019 ]

Research Grant

Researchers: Dr Paul Timpson (Principal investigator) ,  Dr Jennifer Morton

Brief description Inefficient drug response in solid tumour tissue is often a limiting factor in the clinical effectiveness of cancer therapies. Using cutting-edge imaging technology and 3D models that mimic the disease, we have mapped areas of poor drug response within distinct regions of tumours with low oxygen levels known as hypoxia. Here, we will specifically target factors limiting efficient drug targeting in these areas to improve the encouraging anti-cancer profile of AKT inhibitors in pancreatic cancer.

Funding Amount $AUD 699,436.09

Funding Scheme Project Grants

Notes Standard Project Grant