Reactivities of CD8 T cells to mutated neo-antigens in lung malignancies [ 2016 - 2018 ]

Research Grant

Researchers: Prof Bruce Robinson (Principal investigator) ,  A/Pr Mark Watson ,  Prof Jenette Creaney ,  Prof Richard Lake

Brief description Tumours express mutated proteins (called ‘neo-antigens’) which can be targets of powerful killer T cells which can destroy cancer cells. To understand why these cells fail to cure most cancers we will study neo-antigens identified by modern DNA sequencing methods to identify these neo-antigens & the responses to them. Then it will be possible to design trials in individual patients, e.g. personalised vaccines to ‘force’ the immune system to attack cells bearing these neo-antigens.

Funding Amount $AUD 680,759.64

Funding Scheme Project Grants

Notes Standard Project Grant