Towards the rational design of calcium sensing receptor allosteric modulators for the treatment of osteoporosis and calcium handling disorders [ 2018 - 2020 ]

Research Grant

Researchers: Dr Katie Leach (Principal investigator) ,  Dr Ben Capuano ,  Dr Karen Gregory ,  Prof Arthur Conigrave

Brief description Drugs that target the human calcium sensing receptor can be too strong or too weak, resulting in side effects or lack of efficacy. This proposal thus seeks to establish whether the strength of drug activity can be rationally altered and exploited to treat different disease states by fine-tuning CaSR activity in a disease-specific manner.

Funding Amount $AUD 751,769.66

Funding Scheme Project Grants

Notes Standard Project Grant