Rapid HIV-1 tropism testing using novel, soluble mimics of the HIV-1 coreceptors CCR5 and CXCR4 [ 2011 - 2012 ]

Research Grant

Researchers: Prof Paul Gorry (Principal investigator) ,  A/Pr Martin Stone ,  Dr Jasminka Sterjovski ,  Prof Melissa Churchill

Brief description This proposal seeks to develop an inexpensive assay to determine whether HIV patients will benefit from treatment with new drugs referred to as CCR5 antagonists. These are effective against HIV strains that use the CCR5 coreceptor, therefore a patient�s HIV coreceptor usage must be assessed before commencing therapy. Current assays are complicated, slow and expensive. Using novel, soluble mimics of the coreceptors we will develop an ELISA based test that can be operated using standard equipment.

Funding Amount $AUD 163,426.42

Funding Scheme NHMRC Development Grants

Notes Development Grant