Randomised trial of homocysteine lowering treatment of depression in later life (B-VITAge) [ 2009 - 2012 ]

Research Grant

Researchers: Prof Osvaldo Almeida (Principal investigator) ,  A/Pr Kieran Mccaul ,  Prof Leon Flicker

Brief description The causes of depression in later life are varied and complex, but available evidence suggests that cardiovascular disease plays an important role. High homocysteine (a robust risk factor for myocardial infarction and strokes) accounts for about 20% of all cases of depression in older age. We have previously shown that treatment with vitamins B12, B6 and folate reduces homocysteine. We propose to run a trial to test if lowering homocysteine decreases the severity and prevalence of depression.

Funding Amount $AUD 775,530.14

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant