Randomised phase III trial of adjuvant radiotherapy versus observation following breast conserving surgery and endocrine therapy in patients with molecularly characterised low-risk luminal A early breast cancer [ 2016 - ]

Research Grant

Researchers: Prof Boon Chua (Principal investigator) ,  A/Pr Nicholas Wilcken ,  A/Pr Prudence Francis ,  Prof Andrew Spillane ,  Prof Gregory Mann
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Brief description Radiotherapy after surgery for early breast cancer decreases recurrence but its benefit varies. Thus, it is important to identify low-risk patients who are unlikely to benefit from radiotherapy, sparing them its toxicity and costs. We propose a randomised study to investigate if patients whose breast cancer is postulated to be low-risk based on PAM50 (a 50-gene test) may safely omit radiotherapy after surgery. If successful, these patients will be able to avoid the risks of over-treatment.

Funding Amount $4,087,188.00

Funding Scheme Project Grants

Notes Standard Project Grant