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Randomised phase II trial of neoadjuvant chemotherapy +/- concurrent aromatase inhibitor endocrine therapy to down-stage large oestrogen receptor positive breast cancer (ANZ 1401 ELIMINATE)

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Murray, Nicholas ; Breast Cancer Trials (BCT) ; Breast Cancer Trials (BCT)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.58080/RFSH-9S54&rft.title=Randomised phase II trial of neoadjuvant chemotherapy +/- concurrent aromatase inhibitor endocrine therapy to down-stage large oestrogen receptor positive breast cancer (ANZ 1401 ELIMINATE)&rft.identifier=http://doi.org/10.58080/RFSH-9S54&rft.publisher=Breast Cancer Trials (BCT)&rft.description=* Dataset of 134 women with ER-positive, HER2-negative grade 2/3 invasive breast cancer greater than 20mm. *Randomised 2:1 to receive either standard neoadjuvant chemotherapy concurrently with aromatase inhibitor (89 patients) or standard neoadjuvant chemotherapy only (45 patients) for 18-24 weeks. * Rate of downstaging to pathologic stage 0 or 1A, pCR at time of surgery data. * Median breast tumour volume percentage decrease, rate of breast conserving surgery, SAE rates data.&rft.creator=Murray, Nicholas &rft.creator=Breast Cancer Trials (BCT) &rft.creator=Breast Cancer Trials (BCT) &rft.date=2023&rft.relation=https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=ACTRN12614000515695&rft_subject=Chemotherapy&rft.type=dataset&rft.language=English Access the data
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* Dataset of 134 women with ER-positive, HER2-negative grade 2/3 invasive breast cancer greater than 20mm. *Randomised 2:1 to receive either standard neoadjuvant chemotherapy concurrently with aromatase inhibitor (89 patients) or standard neoadjuvant chemotherapy only (45 patients) for 18-24 weeks. * Rate of downstaging to pathologic stage 0 or 1A, pCR at time of surgery data. * Median breast tumour volume percentage decrease, rate of breast conserving surgery, SAE rates data.

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HeSANDA 1.0.0

Issued: 2023

Available: 2023

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Chemotherapy |

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Breast Cancer Trials (BCT)

ROR : https://ror.org/00j1vsg87

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