RAGE and ACE2 shedding as therapeutic targets in diabetes and cardiovascular disease [ 2017 - 2019 ]

Research Grant

Researchers: Prof Merlin Thomas (Principal investigator) ,  Dr Christos Tikellis ,  Prof Karin Jandeleit-Dahm ,  Prof Stephen Wilton

Brief description We have previously demonstrated the pivotal role of two shed proteins, Receptor for Advanced Glycation End-products (RAGE) and Angiotensin Converting Enzyme Receptor 2 (ACE2) in heart disease and diabetic complications. In this project, we will use a novel technologies to modify shedding of these proteins from the cell surface and alter their ability to cause disease.

Funding Amount $AUD 765,984.91

Funding Scheme Project Grants

Notes Standard Project Grant