grant

Protective roles for protease-activated receptor 2 (PAR2) in parasitic and autoimmune diseases [ 2009 - 2012 ]

Also known as: Investigating a new therapy for immune system diseases

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/566955]

Researchers: A/Pr Thomas Cocks (Principal investigator) ,  E/Pr Els Meeusen ,  Prof Robin Gasser

Brief description Parasite infection has unique and specific effects on the human immune system which can prevent allergy and diseases such as diabetes and multiple sclerosis (MS). We have discovered a drug which can cause the immune system to behave in a similar way to that observed during a parasite infection. This project will explore how the drug mimics a parasite and examine the potential of this treatment to prevent MS using a mouse model of this disease.

Funding Amount $AUD 483,421.97

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Animal models of multiple sclerosis | Autoimmune diseases | Biomedical and Clinical Sciences | G protein-coupled receptors | Hypersensitivity | Immune regulation | Immunotherapy | Medical Biochemistry - Carbohydrates | Medical Biochemistry and Metabolomics | Multiple sclerosis | Parasite infection | Parasitic infection | Receptor mimetic |
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