Protecting against malaria through liver-resident memory T cells [ 2018 - ]

Research Grant

Researchers: Dr Daniel Fernandez-Ruiz (Principal investigator) ,  A/Pr David Bowen ,  A/Pr Irina Caminschi ,  A/Pr Scott Mueller ,  Dr Laura Mackay
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Brief description We have shown that formation of liver-resident memory T cells (Trm), a newly discovered type of immune cells, can be induced by an innovative vaccination strategy called prime and trap for highly efficient protection against malaria in mice. Here, we will enhance prime and trap vaccination efficacy by defining the conditions that maximize liver Trm-mediated protection and will characterize simian and human liver Trm cells, paving the way to create the most efficient human malaria vaccine to date

Funding Amount $1,196,853.00

Funding Scheme Project Grants

Notes Standard Project Grant