Protease-activated receptor-1 (PAR-1) and regulation of Helicobacter pylori induced mucosal inflammation [ 2008 - 2010 ]

Research Grant

Researchers: Prof Philip Sutton (Principal investigator) ,  A/Pr Richard Ferrero ,  Dr Janet Wee ,  Prof Hazel Mitchell

Brief description Helicobacter pylori infections cause chronic gastritis which in some people results in stomach cancer or ulcers. We have identified a novel host factor, PAR-1, important for preventing this inflammation. We will use mice to identify how this molecule protects against gastritis and samples from patients to examine its importance in human disease. This will help explain why these diseases develop in some people but not others and perhaps allow identification of those at risk of developing disease.

Funding Amount $AUD 478,090.81

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant