grant

Progesterone signalling in normal and malignant breast relies on chromosomal positioning of progesterone receptor [ 2009 - 2011 ]

Also known as: Chromosomal positioning of progesterone receptor in normal and malignant breast

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/570865]

Researchers: Prof Christine Clarke (Principal investigator) ,  Dr Justine Graham

Brief description The cell nucleus carries genetic information that directs cell function. The nucleus is organised into compartments, which are altered in breast cancer, leading to altered function. The ovarian hormone progesterone acts via a receptor, which clumps into foci in the nucleus when active. In cancers, this clumping is disrupted. In this project we will work out how these foci control cell function, and how this leads to the specific functions of progesterone in normal breast and breast cancers.

Funding Amount $AUD 569,346.84

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Nutrition and Dietetics | Nutritional Science | breast cancer | breast neoplasms | gene expression | progesterone | steroid hormone action | steroid hormone receptors | women's health |
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