Full description
development of NMR techniques in view of pharmaceutical applications. This involves (i) rapid structure determinations of small molecules bound to target proteins and (ii) the determination of three-dimensional structures of protein-protein complexes. implementation and development of selective labelling strategies for proteins, including in vitro expression, site-directed labelling techniques established by Prof. Peter Schultz, Scripps. determination of the three-dimensional structure of medically important proteins and protein domains. Many projects result from a long-standing collaboration with Prof. Nicholas E. Dixon (University of Wollongong). 3D structure determinations of protein domains of unknown structure Subjects
nuclear magnetic resonance |
Chemical Sciences |
NMR |
Physical Chemistry (Incl. Structural) |
Structural Chemistry and Spectroscopy |
lanthanides |
protein structure |
pseudocontact shifts |
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