Production of humanised mouse models for haemoglobin E and 0-thalassaemia [ 2006 - 2010 ]

Research Grant

Researchers: Dr Duangporn Jamsai (Principal investigator)

Brief description The proposed study aims to identify and characterise genes critical to male fertility using two mouse models of infertility: 1) Joey mouse line: an ENU induced model of sperm abnormalities. Following linkage analysis, candidate genes will be selected for sequencing to identify the causal mutation. 2) Ggn knockout mice. The role of the testis-specific gene, Ggn will be characterised through a phenotypic analysis of Ggn knockout mice and a series of expression and biochemical analyses. Both models will be of direct value in the identification of commercially relevant contraceptive targets, as well as furthering our understanding of male reproductive function.

Funding Amount $AUD 280,693.50

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF