Processes underlying establishment and maintenance of the latent HIV resevoir and potential impact of integrase inhibitors [ 2008 - 2011 ]

Research Grant

Researchers: Dr John Zaunders (Principal investigator) ,  Dr Kazuo Suzuki ,  Prof John Murray

Brief description Therapy for HIV-infected individuals is currently able to control the growth of the virus, but cannot eradicate the viral infection. This is due to a pool of CD4+ T lymphocytes which contain HIV DNA in a latent state, ready to reactivate as soon as therapy is interrupted. This project aims to better understand how this pool of latently infected CD4+ T lymphocytes is established and maintained, particularly how it is linked to the essential T cell survival signal from interleukin 7.

Funding Amount $AUD 318,044.94

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant