Prevention of beta cell destruction in type 1 diabetes by immunotherapy using parasite-derived molecules. [ 2011 - 2014 ]

Research Grant

Researchers: A/Pr Bronwyn O'Brien (Principal investigator) ,  Dr Mark Robinson ,  Dr Sheila Donnelly ,  Prof Ann Simpson ,  Prof John Dalton

Brief description To prevent type 1 diabetes, compounds that avert the autoimmune destruction of beta cells are needed. We are exploiting the potential of ñworm therapyî by mimicking the beneficial immune effects of parasite worm infection. We have identified the molecules that the parasite uses to influence host immune responses. We have demonstrated that these novel immune-modulatory worm molecules prevent diabetes in a mouse model. This offers great potential for the development of therapeutic interventions.

Funding Amount $AUD 518,443.49

Funding Scheme Project Grants

Notes Standard Project Grant