Preventing the evolution of transmissible nitroimidazole resistance in Mycobacterium tuberculosis [ 2018 - ]

Research Grant

Researchers: A/Pr Colin Jackson (Principal investigator) ,  Dr Chris Greening ,  Dr Nicholas West ,  Prof Greg Cook ,  Prof William Denny

Brief description Tuberculosis kills more people than any other infectious disease. Unfortunately, the drugs available to us to treat TB are losing their efficacy due to the evolution of drug resistance. A new class of drugs, nitroimidazoles, has been developed, but there is a risk that the bacterium that causes TB will develop resistance to these compounds too. We will identify resistance mutations before they occur in the wild, to help identify them and find new compounds for which resistance cannot develop.

Funding Amount $664,463.00

Funding Scheme Project Grants

Notes Standard Project Grant