The preferential release of young insulin secretory granules. [ 2018 - ]

Research Grant

Researchers: Dr Melkam Kebede (Principal investigator) ,  Dr Mark Larance ,  Prof Peter Thorn

Brief description The aim of this study is to investigate the cause of reduced glucose induced insulin secretion in type 2 diabetes. In pancreatic beta-cells, insulin is packaged and stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that insulin SGs exist in two functionally distinct pools; and one pool is preferentially secreted upon stimulation. How a cell can differentiate the two SG pools is unclear, and we will address this issue in this project.

Funding Amount $670,005.00

Funding Scheme Project Grants

Notes Standard Project Grant