Predicting drug-drug interactions due to tyrosine kinase inhibitors: Inhibition of drug metabolising enzymes and transporters [ 2013 - 2015 ]

Research Grant

Researchers: Prof John Miners (Principal investigator) ,  Dr Andrew Rowland ,  E/Pr Peter Mackenzie ,  Prof Kathleen Knights ,  Prof Ross Mckinnon

Brief description Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.

Funding Amount $AUD 535,495.14

Funding Scheme Project Grants

Notes Standard Project Grant