grant

Preclinical optimisation of intrauterine transplantation of fetal mesenchymal stem cells for osteogenesis imperfecta. [ 2010 - 2013 ]

Also known as: Fetal stem cell therapy for Osteogenesis Imperfecta

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/631641]

Researchers: Prof Nicholas Fisk (Principal investigator) ,  A/Pr Allison Pettit ,  A/Pr Kiarash Khosrotehrani ,  Dr Liza Raggatt

Brief description Osteogenesis imperfecta is a genetic disorder causing brittle bones and fractures. Currently there is no good treatment. Transplanting stem cells before birth should allow them to build healthy bones early in life. Despite promising effects in animals, stem cell uptake is too low to prevent all fractures and ameliorate pain and deformity. We are studying how to improve the uptake of stem cells given to the fetus and neonate, in order to develop a treatment suitable for eventual use in humans.

Funding Amount $AUD 600,932.15

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Birth defects | Bone growth and fracture healing | Congenital skeletal defects | Fetal medicine | Fetal therapy | Foetal Development and Medicine | Medical and Health Sciences | Osteogenesis | Osteogenesis imperfecta | Paediatrics and Reproductive Medicine | Stem cell therapy | Stem cells | Transplantation |
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