Postsynaptic signalling systems that sustain the nerve-muscle synapse [ 2009 - 2012 ]

Research Grant

Researchers: A/Pr William Phillips (Principal investigator) ,  A/Pr Peter Noakes ,  A/Pr Stephen Reddel

Brief description Neuromuscular junctions (NMJ) are the synapses through which motor nerves control our voluntary muscle cells. This project will investigate the molecular signalling system between nerve and muscle that helps maintain healthy NMJs. Normal ageing involves a progressive decline in muscle strength, often leading to loss of independence in the elderly. We will use a mouse model to test whether a breakdown of the NMJ signalling system contributes to the loss of strength in old age.

Funding Amount $AUD 598,041.54

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant