Post-transcriptional regulation of plasminogen activator inhibitor 2 gene expression [ 2008 - 2010 ]

Research Grant

Researchers: Prof Robert Medcalf (Principal investigator) ,  Dr Stan Stasinopoulos ,  Dr Yoshikuni Nagamine

Brief description Plasminogen activator inhibitor type 2 (PAI-2) is a protease inhibitor that has intracellular and extracellular functions. The PAI-2 gene is highly regulated at the level of PAI-2 mRNA stability. We have identified regions within the PAI-2 transcript essential for this regulation and a number of novel proteins that engage these regions. This project is aimed at understanding how these and other proteins control PAI-2 expression at the mRNA level.

Funding Amount $AUD 508,838.81

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant