Positive modulation of ionotropic GABA receptors [ 2006 - 2008 ]

Research Grant

Researchers: E/Pr Graham Johnston (Principal investigator) ,  Dr Kenneth Mewett ,  Prof Jane Hanrahan ,  Prof Mary Collins Chebib

Brief description Substances that enhance the action of the inhibitory neurotransmitter GABA in the brain are amongst the most widely used drugs. They include many anaesthetics, anxiolytics and sedatives. Their enhancing action is mediated by increasing the effectiveness of GABA acting on GABA receptors, in particular the subtype of GABA receptors known as GABA-A receptors. This action, termed positive modulation, is poorly understood in molecular terms. Our discovery of second order modulators that only act in conjunction with first order modulators adds an exciting new dimension to the concept of influencing the ways in which GABA receptors can be modulated. This offers a new approach to the development of therapeutic agents acting on GABA receptors and thus the treatement of important disorders such as anxiety, epilepsy and insomnia.

Funding Amount $AUD 540,023.48

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant