A polypill to prevent genome damage [ 2007 - 2008 ]

Research Grant

Researchers: Prof Bruce Armstrong (Principal investigator) ,  Ms Peta Forder ,  Prof Michael Fenech

Brief description It has become increasingly evident that damage to the genetic material in cells (DNA) is a fundamental initiating cause of cancer and accelerated ageing. Furthermore it has been shown recently that moderate deficiencies of certain vitamins and minerals can cause damage to DNA at a level that is observed for carcinogenic doses of radiation and toxic chemicals. In addition studies have shown that supplementation with certain vitamins resulted in a reduction of damage to DNA. The aims of this research is to determine whether daily intake of a pill containing certain vitamins and minerals causes a reduction in DNA damage in blood cells. The expected ultimate outcome is a cancer prevention strategy based on reducing the risk of damage to DNA.

Funding Amount $AUD 407,033.20

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant