Platelet glycoprotein proteolysis: novel mechanisms and risk factors [ 2018 - 2020 ]

Research Grant

Researchers: A/Pr Elizabeth Gardiner (Principal investigator) ,  A/Pr Giuseppe Verdile ,  A/Pr Robert Andrews ,  Prof Christopher Ward ,  Prof Michael Berndt

Brief description Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.

Funding Amount $AUD 441,473.49

Funding Scheme Project Grants

Notes Standard Project Grant