grant

Plasmodium falciparum neutral aminopeptidases: structure-function analysis for the discovery of anti-malarial drugs. [ 2009 - 2011 ]

Also known as: A path to new anti-malarial drug discoveries by understanding enzyme structure

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/571917]

Researchers: A/Pr Donald Gardiner (Principal investigator) ,  Dr Sheena Mcgowan Prof John Dalton

Brief description Malaria is the world's most prevalent parasitic disease. Due to the spread of drug resistant parasites there is an urgent need to identify new anti-malaria targets and develop new drugs. We have shown that two enzymes, termed neutral aminopeptidases, are essential to the parasite's survival in the host. In this proposal we will obtain the structure of these enzymes and bring forth novel lead compounds that will form the basis of a new class of anti-malaria treatment.

Funding Amount $AUD 634,027.79

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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