Place, Experience, and Physiology: A Multimodal Investigation of Parkinson’s Disease in Regional Australia - Electrophysiological, Clinical, Motor and Cognitive Data

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This dataset comprises clinical, neuropsychological, motor, postural, and electrophysiological data collected from adults with mild-to-moderate Parkinson's disease (PD) and age-matched healthy controls recruited from regional New South Wales, Australia. Data were collected between June 2022 and March 2024 across five in-person assessment locations. PD participants completed assessments at up to three timepoints (baseline, 6 months, and 12 months); control participants were assessed at baseline only. Clinical measures included the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Neuropsychological assessments comprised the Montreal Cognitive Assessment (MoCA), the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG), the Patient Health Questionnaire-9 (PHQ-9), and the Generalised Anxiety Disorder-7 (GAD-7). Motor function was assessed via the Finger Tapping Test (FTT), and postural control was measured using a Bertec force plate under eyes-open and eyes-closed conditions. Electroencephalographic (EEG) data were recorded using a Wearable Sensing DSI-24 dry electrode headset during a visual Go/NoGo task, and resting state. The cross-sectional data were used to compare cognitive, motor, postural, and electrophysiological profiles between PD and control groups. The longitudinal data were used to examine individual trajectories of change across biomarkers over 12 months in the PD group, including the predictive role of baseline disease severity. All PD participants were assessed in their medicated 'ON' state.