Physiological function of Nedd4-2 in regulating the epithelial sodium channel and cystic fibrosis transmembrane conductance regulator [ 2012 - 2015 ]

Also known as: Control of sodium and chloride transport by an enzyme involved in protein modification

Research Grant

[Cite as]

Researchers: Prof Sharad Kumar (Principal investigator)

Brief description Optimal transport of sodium and chloride ions is essential for the maintenance of electrolyte balance, blood volume, blood pressure and lung function. We are studying the control of a key sodium channel (the epithelial sodium channel) and a key chloride channel (cystic fibrosis transmembrane conductance regulator) by an enzyme called Nedd4-2. This project will enable us to understand how Nedd4-2 regulates these two ion channels and to study the pathological consequences of the loss of Nedd4-2.

Funding Amount $AUD 949,572.35

Funding Scheme Project Grants

Notes Standard Project Grant

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