grant

Phosphorylation of synaptic vesicle glycoprotein 2 (SV2) regulates endocytosis of synaptotagmin for synaptic transmission [ 2013 - 2015 ]

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1052494]

Researchers: Prof Phillip Robinson (Principal investigator) ,  Dr Mark Graham

Brief description Antiepileptic drugs typically target ion transporters or neurotransmitter receptors. Synaptic vesicle glycoprotein 2 (SV2) is a rare example of a synaptic vesicle recycling protein that is the target of an antiepileptic drug. It also binds botulinum and tetanus neurotoxins. We discovered SV2 contains activity-dependent signalling molecules. Charactersation of these molecules and will allow a deeper understanding of the molecular basis for its role in epilepsy and toxin action.

Funding Amount $AUD 613,311.63

Funding Scheme Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Identifiers
Viewed: [[ro.stat.viewed]]
ACN 633 798 857