[Cite as http://purl.org/au-research/grants/nhmrc/519704]
Prof Michael Jennings
Prof Sean Grimmond
Brief description Certain bacterial DNA repeats are prone to hyper mutation. Genes with these repeats, Contingency genes, are randomly switched on and off. This process, phase variation , generates diversity in a population. Recently we described a new class of contingency gene that methylates DNA. On-off switching of this gene leads to random switching of multiple genes; the phasevarion . We will define the impact of this system in bacteria causing meningitis and STDs.
Funding Amount $AUD 557,939.08
Funding Scheme NHMRC Project Grants
Standard Project Grant