grant

Phase variable protein glycosylation in bacteria mucosal pathogens and its role in immune evasion [ 2012 - 2016 ]

Also known as: Sugar-coated bacteria: how and why pathogens decorate themselves with sugars

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1031542]

Researchers: A/Pr Benjamin Schulz (Principal investigator)

Brief description The bacterium Haemophilus influenzae is a leading cause of ear infections. Hearing loss from these infections can seriously affect literacy and educational performance. As no vaccine is available, we will research how the bacterium makes the HMW protein that is important in infection. We will study how sugars are added to the surface of this protein so that the bacterium can escape the immune system, its role in related bacteria and how it may be used in a vaccine.

Funding Amount $AUD 409,728.86

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF

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Subjects
Haemophilus influenzae | Medical and Health Sciences | Medical Microbiology | Medical Bacteriology | Neisseria meningitidis | chronic obstructive pulmonary disease (COPD) | glycoproteins | immune evasion | mass spectrometry | meningitis | otitis media | phase variation |
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