A Pharmacological Targeting Approach Implementing Albumin as a Carrier of a Novel Chemotherapeutic [ 2015 - ]

Research Grant

Researchers: Dr Danuta Kalinowski (Principal investigator)

Brief description Novel agents that bind essential metals have emerged as a potential avenue for cancer therapy. My laboratory has developed potent anti-cancer agents, such as Dp44mT, that bind to the plasma protein, albumin. Notably, the uptake of Dp44mT into tumour cells was increased in the presence of albumin. My research will examine the mechanisms in the albumin-mediated increase in Dp44mT uptake into tumour cells, with the goal to develop albumin nanoparticles to selectively deliver our agents to tumours.

Funding Amount $411,768.00

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF