Pharmacological development of synthetic analogues of cytochrome P450-mediated omega-3 fatty acid epoxides as novel anti-metastatic agents [ 2012 - 2014 ]

Research Grant

Researchers: Prof Michael Murray (Principal investigator) ,  A/Pr Colin Duke ,  A/Pr Colin Dunstan ,  A/Pr Lai-Ming Ching ,  Dr Pei (Sarah) Cui

Brief description Dietary ?-3 and ?-6 fatty acids respectively decrease and increase the risk of cancer spread, or metastasis. We have found that ?-3 fatty acid epoxide metabolites inhibit the growth and migration of tumour cells. We have prepared derivatives of these ?-3 epoxides that retain anti-cancer properties in cells. In this project we will develop analogues of these ?-3 epoxides that are suitable for in vivo testing in animal models of breast cancer metastasis as a new class of potential anti-metastatic drugs.

Funding Amount $AUD 865,174.23

Funding Scheme Project Grants

Notes Standard Project Grant