Personalised medicine markers of anti-EGFR antibody therapy in metastatic colorectal cancer: accelerating clinical translation with collaborative meta-analyses based on individual-participant data [ 2015 - 2018 ]

Research Grant

Researchers: Prof Christos Karapetis (Principal investigator) ,  Prof Michael Sorich ,  Prof Ross Mckinnon

Brief description When selecting cancer therapy we take into account ‘biomarkers’, biological cancer characteristics that predict treatment success. We will work with an international group, the Advanced Colorectal Cancer Database, to analyse individual patient clinical trial data. We intend to validate biomarkers used to select treatment with cetuximab or panitumumab. Cancer genes called KRAS, NRAS, PTEN, PIK3CA, EREG and BRAF will be examined. Our study will provide best evidence for personalised treatment.

Funding Amount $AUD 300,953.79

Funding Scheme Project Grants

Notes Standard Project Grant