Perforinopathy: Immune-disease due to defective perforin function [ 2014 - 2016 ]

Also known as: Regulation of immune cell function

Research Grant

[Cite as]

Researchers: Prof Joseph Trapani (Principal investigator) ,  A/Pr Ilia Voskoboinik

Brief description White blood cells called cytotoxic lymphocytes destroy cancerous cells using special toxic molecules. One of them, perforin, eliminates dangerous cells by punching holes in their membrane. Some individuals that lack perforin become seriously ill in their infancy. Others, that retain some perforin in their lymphocytes can live longer and are at higher risk of developing cancer. We will investigate the causes of partial loss of perforin function and explore novel drug therapies, which should address the problem and restore immune function.

Funding Amount $AUD 671,514.19

Funding Scheme Project Grants

Notes Standard Project Grant

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