PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome [ 2015 - 2018 ]

Research Grant

Researchers: A/Pr Ashley Mansell (Principal investigator) ,  Dr Julie Mcauley

Brief description Fatal Influenza A virus infections are excessive inflammation. We identified the IAV protein PB1-F2 as critical in driving excessive inflammation via activating the host inflammasome complex. Our study evaluates PB1-F2-mediated inflammation contribution to inflammatory responses. Identifying PB1-F2 in emerging IAV strains is invaluable in aiding health policy makers to quickly assess fatal IAV pandemics. Our research will potentially identify treatment targets towards reducing this inflammation

Funding Amount $AUD 663,919.13

Funding Scheme Project Grants

Notes Standard Project Grant