grant

Pathways involved in the insulin-like growth factor (IGF)-independent actions of IGF binding protein-6 [ 2009 - 2011 ]

Also known as: How do proteins regulate cell behaviour?

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/546016]

Researchers: Prof Leon Bach (Principal investigator) ,  Dr Ping Fu Prof Greg Rice

Brief description Insulin-like growth factors (IGFs) are important proteins that regulate growth. When not regulated properly, diseases such as cancer can occur. A family of IGF binding proteins regulates IGFs. IGFBPs may inhibit IGFs and we have shown that one of them, IGFBP-6, decreases growth of some experimental cancers. As well as regulating IGFs, some IGFBPs alter cell behaviour independently of IGFs, and we found that IGFBP-6 stimulates cell movement in this way. We will now determine how this happens.

Funding Amount $AUD 550,724.99

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857