grant

The Pathway Linking Tau and APP in Neurodegeneration [ 2013 - 2017 ]

Also known as: Tau and APP interactions in Neurodegeneration

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1054736]

Researchers: Dr Peng Lei (Principal investigator)

Brief description Recently I co-discovered a novel relationship between the AlzheimerÍs amyloid precursor protein and tau, both of which play a role in regulating neuronal iron levels. I predict that multiple failures in iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of neurodegenerative diseases. I hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.

Funding Amount $AUD 312,085.57

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF

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