Pathophysiology and prevention of methotrexate chemotherapy-induced bone growth defects [ 2008 - 2011 ]

Also known as: Mechanisms and prevention of chemotherapy-induced bone growth defects

Research Grant

[Cite as]

Researchers: Prof Cory Xian (Principal investigator) ,  A/Pr Bruce Foster

Brief description Childhood chemotherapy often causes growth arrest, osteoporosis, and fractures in cancer patients and survivors. Using a rat model, this project will study how the most commonly used chemotherapy drug methotrexate causes bone growth defects and examine any protective effects of two natural-derived substances. This work will increase our knowledge on chemotherapy-induced bone growth defects, and will be useful for developing a preventative treatment.

Funding Amount $AUD 622,598.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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