Paget's disease of bone associated Sequestosome 1/p62 mutations in autophagy-mediated processes and bone resorption [ 2012 - 2015 ]

Research Grant

Researchers: Prof Jiake Xu (Principal investigator) ,  A/Pr Nathan Pavlos ,  Dr Sarah Rea ,  Prof John Walsh ,  Prof Thomas Ratajczak

Brief description Paget’s disease of bone (PDB) is a common, chronic bone disorder characterized by focal lesions of increased bone degradation initiated by giant overactive osteoclasts. Subsequent bone formation is irregular, resulting in bones that are structurally weak. Genetic mutations are a common cause of PDB in Caucasians. Understanding the genetic mutations and their regulation on bone cells may lead to the discovery of a new drug target for the treatment of PDB.

Funding Amount $AUD 474,892.07

Funding Scheme Project Grants

Notes Standard Project Grant