OXPHOS upregulation to preserve vision in Leber's Hereditary Optic Neuropathy [ 2014 - 2016 ]

Research Grant

Researchers: A/Pr Ian Trounce (Principal investigator) ,  Prof David Mackey ,  Prof Jonathan Crowston

Brief description Leber's Hereditary Optic Neuropathy (LHON) is a devastating blinding disease that preferentially affects young men. Sufferers have normal vision until teenage years or their twenties when a rapid loss of vision occurs that results in permanent blindness. It is caused by genetic changes in the mitochondrial DNA that we inherit from our mothers. The mitochondria are the cells' energy generators. We aim to use molecules similar to female hormones to boost energy as a new treatment to preserve vision in at-risk LHON individuals.

Funding Amount $AUD 496,874.43

Funding Scheme Project Grants

Notes Standard Project Grant