Oxidative regulation of the Na pump- a new player in vascular function in health and disease [ 2015 - 2017 ]

Research Grant

Researchers: Prof Gemma Figtree (Principal investigator) ,  A/Pr Ravinay Bhindi ,  Dr Ben Davies ,  Dr Christina Bursill ,  Prof Clare Hawkins
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Brief description Oxidative stress is a major player in hypertension, atherosclerosis, diabetes and ageing, but we have struggled to develop a therapy to successfully combat in heart and vascular cells in large clinical trials. We have discovered a new role for membrane protein FXYD1, to protect key heart and vascular proteins from functional impairment secondary to oxidative stress. We will investigate its role in protecting against vascular disease, and test novel therapies based on this endogenous protector.

Funding Amount $AUD 504,427.81

Funding Scheme Project Grants

Notes Standard Project Grant