Osteoclast- specific gene regulation [ 2002 - 2004 ]

Research Grant

Researchers: Dr Alan Cassady (Principal investigator) ,  Prof David Hume

Brief description Osteoporosis is a pathological loss of bone that affects many Australians. It occurs because of an excessive release of calcium from bone that is caused by the overactivity of the cells that break down bone, osteoclasts. We have studied two genes that are involved in the way these cells work and by a close examination of the the way they are regulated we hope to understand how osteoclasts are derived and how their activity is controlled. In particular we will look at two newly dicovered osteoclast regulators called PPAR-gamma and PPAR-delta. These offer the opportunity for the development in the future of new, alternative drugs for the treatment of osteoporosis.

Funding Amount $AUD 226,650.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant