Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours [ 2017 - 2019 ]

Research Grant

Researchers: Prof Michelle Haber (Principal investigator) ,  A/Pr David Ziegler ,  Prof Murray Norris

Brief description Paediatric neuroblastoma and brain tumours, which often have dismal outcomes despite intensive therapy, have high levels of polyamines, which are essential for cell growth. We have shown that depleting polyamines, combined with chemotherapy, represents a highly promising therapy for neuroblastoma. We will make this exciting new treatment approach even more effective by comparing three ways of enhancing polyamine depletion, as a precursor to future neuroblastoma and brain tumour clinical trials.

Funding Amount $AUD 950,143.12

Funding Scheme Project Grants

Notes Standard Project Grant