Optimising efficacy of a peptide derived against the alpha-interacting domain of the L-type calcium channel in reduction of ischemia-reperfusion injury [ 2013 - 2016 ]

Research Grant

Researchers: A/Pr Livia Hool (Principal investigator) ,  A/Pr Ben Corry ,  A/Pr Killugudi Swaminatha-Iyer

Brief description A heart attack is associated with an increase in free radicals and calcium in heart muscle cells. The function of the L-type calcium channel, a protein responsible for calcium entry into cells, is altered by free radicals and this contributes to the development of heart disease. We now have considerable proof of concept that a peptide derived against the L-type calcium channel can decrease heart injury. We will optimise efficacy and delivery of the peptide to prevent heart failure.

Funding Amount $AUD 405,063.39

Funding Scheme Project Grants

Notes Standard Project Grant