The ontogeny of TLR mediated innate immune function in normal and atopic children [ 2007 - 2009 ]

Research Grant

Researchers: Prof Susan Prescott (Principal investigator) ,  Catherine Thornton (Nee Jones) ,  Dr Janet Dunstan

Brief description Bacteria are first recognised by the immune system though primitive innate immune pathways which are highly conserved through evolution. The activation of these pathways is critical for the maturation of the immune system. This may explain the rise in immune diseases with cleaner environments (and less innate immune activation). We speculate that functional differences (as a result of environmental or genetic factors) are implicated in the rising rates of allergic disease. This is the first study to document normal maturation of these innate pathways in early childhood, and to compare this in allergic and nonallergic children. We will do this using existing samples collected as part of previous cohort studies. This study is the logical next step in the quest to define allergy pathogenesis. Whatever the outcome, the findings will be of enormous significance. A better understanding of the development of these pathways is also likely to contribute to more avenues for better-targeted treatment and prevention.

Funding Amount $AUD 463,328.39

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant