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Our own neuropsyhological study of obsessive compulsive disorder (OCD), Depression and Panic Disorder has identified specific cognitive deficits in OCD that implicate dysfunction of prefrontal and striatal brain regions. This study compared patients with OCD, patients with Depression, and normal control subjects while they performed cognitive tasks of response inhibition during brain scanning. The identification of differences between the groups in relation to the patterns of brain activation associated with response inhibition processes allowed a more precise understanding of the nature of brain function in OCD and Depression, and enabled us to delineate whether patterns of brain activation among OCD patients are specific to the disorder, or are related to comorbid depression. Approximately 30 patients (non-medicated) were recruited from the Royal Melbourne Hospital/University of Melbourne Psychology Clinic. All participants took part in interviews, MRI and PET scanning. Time Period: 1997 to 1999 Subjects
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