Obesity, insulin resistance and hepatocarcinogenesis: metabolic mediators and molecular mechanisms [ 2009 - 2013 ]

Research Grant

Researchers: Dr Claire Larter (Principal investigator) ,  The Australian National University (Managed by)

Brief description Liver cancer (or hepatocellular carcinoma, HCC) is the 3rd most common cause of cancer death, with the incidence in Australia increasing. Recently, it has been shown that obesity, diabetes and fatty liver disease can lead to HCC; this project will explore how metabolic diseases promote HCC. The role of insulin and fatty acids in promoting DNA damage and cell growth will be examined. Understanding how metabolic disease increases HCC risk will improve prevention strategies and possible treatments.

Funding Amount $AUD 199,485.66

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF