grant

NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies [ 2012 - 2017 ]

Also known as: Oxidant-producing proteins as novel targets to combat neurodegenerative diseases

Funded by National Health and Medical Research Council
Managed by Victor Chang Cardiac Research Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1037879]

Researchers: Prof Roland Stocker (Principal investigator)

Brief description The NEURINOX project aims at identifying novel therapeutic targets for neurodegenerative diseases; an increasing health issue for the ageing Australian population. NADPH oxidases (NOX) enzymes, generate reactive oxygen species, and are key regulators of neuroinflammation. Inflammatory dysregulation is characterized by a change in NOX activity. NEURINOX will expound the links between neuroinflammation, NOX enzyme activity & neurodegenerative diseases to identify novel therapeutic targets to treat neuroinflammation.

Funding Amount $AUD 994,846.87

Funding Scheme Targeted Calls

Notes Aust/EU Collaborative Research Grant

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Subjects
Medical and Health Sciences | Neurosciences | Neurology and Neuromuscular Diseases | Parkinson disease | amyotrophic lateral sclerosis | autoimmune disease | enzymes | multiple sclerosis (MS) | neurodegenerative disorders | neuroinflammatory disease | neuropharmacology | oxidative stress | proteomics |
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ACN 633 798 857