De novo mutations and the pathogenesis of childhood-onset autoimmune disease [ 2016 - 2019 ]

Research Grant

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Researchers: Prof Christopher Goodnow (Principal investigator) ,  A/Pr Tony Roscioli Dr Elissa Deenick Dr Melanie Wong Dr Stephen Daley
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Brief description This project aims to reveal the gene abnormalities that cause devastating autoimmune diseases to develop in some children, such as Type 1 diabetes, juvenile arthritis and autoimmune destruction of blood cells. The project will use new technologies to identify alterations in the DNA sequence of a child compared to either of their parents, and to test suspicious DNA alterations in laboratory mice in order to understand the gene effects and evaluate new treatments.

Funding Amount $AUD 1,449,579.56

Funding Scheme Project Grants

Notes Standard Project Grant

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